Deletion of 13q14.3 and not 13q12 is the most common genetic abnormality detected in chronic lymphocytic leukemia cells.
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چکیده
over time with transplant is not warranted. A portion of the sample REFERENCES did stay the same or better, and half were in the average range of 1. Peters C, Balthazor M, Shapiro EG, King RJ, Kollman C, intelligence at outcome on the Stanford Binet Intelligence Scale or Hegland JD, Henslee-Downey J, Trigg ME, Cowan MJ, Sanders J, McCarthy Scales of Children’s Abilities. We also note that, in the Bunin N, Weinstein H, Lenarsky C, Falk P, Harris R, Bowen T, past 2 years, with decreased BMT-related morbidity and mortality Williams TE, Grayson GH, Warkentin P, Sender L, Cool VA, Critand earlier transplant, we are seeing fewer children who are slowing tenden M, Packman S, Kaplan P, Lockman LA, Anderson J, Krivit in development after BMT. W, Wagner J: Outcome of unrelated donor bone marrow transplantation in 40 children with Hurler syndrome. Blood 87:4894, 1996 Charles Peters 2. Francis D, Shaywitz S, Stuebing K, Shaywitz B, Fletcher J: The Elsa G. Shapiro measurement of change: Assessing behavior over time and within a Pediatric Bone Marrow Transplant developmental context, in Lyon GR (ed): Frames of Reference for Pediatric Neurology the Assessment of Learning Disabilities. Baltimore, MD, Paul University of Minnesota Brookes, 1995, p 29 Minneapolis, MN
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Chronic lymphocytic leukemia, biology, new diagnosis and treatment: review article
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Chronic lymphocytic leukemia (CLL) has consistent 13q chromosomal abnormalities detected by conventional cytogenetics. Using interphase cytogenetics we show deletion of a 1-megabase 13q12.3 locus, encompassing the BRCA2 gene, in 80% of 35 CLL cases studied. Homozygous deletion of BRCA2, located within the minimal deletion consensus, was detected in a significant population of cells in 60% of th...
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Loss of genomic material from chromosomal band 13q14.3 is the most common genetic imbalance in B-cell chronic lymphocytic leukemia (B-CLL) and mantle cell lymphoma, pointing to the involvement of this region in a tumor suppressor mechanism. From the minimally deleted region, 3 candidate genes have been isolated, RFP2, BCMS, and BCMSUN. DNA sequence analyses have failed to detect small mutations...
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عنوان ژورنال:
- Blood
دوره 89 2 شماره
صفحات -
تاریخ انتشار 1997